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Manual Therapy Systematic review and meta-analysis

Effectiveness of instrument-assisted soft tissue mobilization for the management of upper body, lower body, and spinal conditions. An updated systematic review with meta-analyses.

Instrument-assisted soft tissue mobilization, a manual therapy technique using handheld tools to work on muscles and connective tissue, is widely used for musculoskeletal pain and restricted movement, but how well it actually works has been unclear. This review pooled data from 46 randomized trials comparing IASTM, usually added to another treatment, against that other treatment alone, across upper body, lower body, and spinal conditions. The combined results showed no statistically significant or clinically meaningful difference in function or pain, and no clinically meaningful change in range of motion. The authors rated the certainty of this evidence as very low, largely because the included trials carried a high risk of bias.

Few studies even reported whether adverse events occurred, and the authors flagged a growing number of IASTM trials appearing in journals of questionable legitimacy, both of which further limit how much confidence can be placed in the existing body of research.

If you've had instrument-assisted soft tissue mobilization, often done with metal or plastic tools glided over the skin, as part of your physiotherapy, this review looked at whether the research actually backs it up as helpful for pain, movement, or daily function. Researchers combined findings from 46 clinical trials covering a wide range of body areas, from shoulders and knees to the spine. The bottom line is that when IASTM was added to other treatments, it did not show a statistically significant or clinically meaningful advantage over those other treatments alone for pain, function, or range of motion.

This doesn't necessarily mean IASTM never helps anyone, but the available trials don't clearly demonstrate a benefit. Importantly, the quality of the underlying studies was rated very low, mainly because of weaknesses in how the trials were designed and conducted. Few studies tracked side effects, and some of the research has appeared in journals with questionable publishing standards, both of which make it harder to trust the findings as a whole.

This is a summary of research, not medical advice. Talk to your own healthcare provider about anything affecting your care.

This review addresses a question many clinicians face when choosing adjunct manual therapy techniques: does adding instrument-assisted soft tissue mobilization (IASTM) to standard treatment improve outcomes in patients with upper body, lower body, or spinal conditions? Pooling 46 randomized controlled trials, the authors found no statistically significant or clinically meaningful difference in function or pain when IASTM was added to other treatment compared with that treatment alone, and no clinically meaningful improvement in range of motion. What this adds to clinical reasoning is a caution against treating IASTM as an evidence-supported add-on for these outcomes, since the pooled estimates (function SMD -0.28, 95% CI -0.66 to 0.09; pain SMD -0.05, 95% CI -0.53 to 0.43, up to one-year follow-up) crossed the line of no effect and the certainty was rated very low throughout, driven by high risk of bias across trials. Because most comparisons involved IASTM plus other treatment versus other treatment alone without a sham arm, any apparent benefit in individual trials could partly reflect attention or expectation rather than the technique itself. The review does not establish that IASTM is ineffective in all circumstances, only that current trial evidence does not support clinically meaningful benefit, and only 10 of 46 trials reported on adverse events, leaving safety largely unaddressed.

The authors also note a concerning rise in IASTM trials published in journals of uncertain legitimacy, which clinicians should factor in when evaluating future literature on this technique.

1

Across 46 randomized controlled trials, adding instrument-assisted soft tissue mobilization (IASTM) to other treatment did not produce a statistically significant or clinically meaningful improvement in function or pain compared with other treatment alone.

2

No clinically meaningful improvements in range of motion were found with IASTM, and all pooled evidence was rated very low quality due to high risk of bias in the included trials.

3

Only 10 of the 46 included trials assessed and reported IASTM-related adverse events, and the review authors noted a rise in IASTM studies published in suspected predatory journals.

Source

Disability and rehabilitation

Nazari G, Bobos P, Lu SZ et al. · 2023

doi: 10.1080/09638288.2022.2070288

Read paper →
Previously in Manual Therapy
2026-10-19The Comparative Efficacy of Treatments for Cervicogenic Headache: A Systematic Review and Network Meta-Analysis of Randomised Controlled Trials.2026-10-18Efficacy of percutaneous needle electrolysis versus dry needling in musculoskeletal pain: A systematic review and meta-analysis.2026-10-17Effects of Instrument-Assisted Soft Tissue Mobilization and Extracorporeal Shock Wave Therapy in Individuals With Lateral Elbow Pain: A Randomized Single-Blind Clinical Trial. Browse the full Manual Therapy archive →
A note on accuracy

Summaries are AI-generated from each paper's abstract and are for learning, not clinical decision-making. They may miss nuance or occasionally misstate details from the source, so always read the original paper before applying findings in practice. Nothing on this site is medical advice.