Efficacy of two intervention approaches on functional walking capacity and balance in children with Duchene muscular dystrophy.
Featured on Physle Daily · Thursday, 20 August 2026
Boys with Duchenne muscular dystrophy gradually lose muscle strength, which affects the balance control and walking ability they rely on for everyday activities. This trial asked whether adding treadmill training to a standard physical therapy program would help more than adding stationary bicycle training. Thirty boys aged six to ten were randomly assigned to one of the two exercise types alongside the same base physical therapy program, three times a week for three months.
Both groups improved on measures of walking capacity and balance from before to after treatment, but the treadmill group showed significantly greater improvement than the bicycle group when the two were compared directly. This is interesting because it suggests the type of aerobic exercise added to therapy may matter for these children, not just whether aerobic exercise is included at all. The main limitation is the small sample size of just thirty boys split across two groups, which limits how confidently these results can be generalized.
If your child has Duchenne muscular dystrophy, you may already know that weakening muscles can make walking and staying balanced harder over time. This study looked at two ways of adding aerobic exercise to physical therapy for boys aged six to ten: one group used a stationary bicycle, the other used a treadmill, alongside the same therapy program for three months. Both groups showed improvement in how far they could walk and in balance testing after the three months.
When the two approaches were compared, the treadmill group showed better improvement than the bicycle group. This is a hopeful early signal that the specific type of aerobic training added to therapy could make a difference, though it does not tell us why or by how much this matters for daily life. It is important to keep in mind that this was a small study with only thirty boys total, split between two groups.
That means the findings, while promising, need to be confirmed in larger studies before we can be confident about which approach works best.
This is a summary of research, not medical advice. Talk to your own healthcare provider about anything affecting your care.
This randomised controlled trial compared two aerobic training modalities, cycle ergometry versus treadmill walking, both added to a standard physical therapy program, in thirty boys with Duchenne muscular dystrophy aged six to ten. Group A received physical therapy plus bicycle ergometer training and Group B received the same physical therapy plus treadmill training, each for one hour three times weekly over three months.
Outcomes were the six-minute walk test for functional walking capacity and Biodex balance system measures for postural control. Both groups showed statistically significant within-group improvement from pre to post treatment (P<0.05) on all measured variables. The between-group comparison favoured the treadmill group, with significantly greater post-treatment improvement reported across all measures.
This design allows a direct comparison between the two active interventions rather than relying on within-group change alone, which strengthens the interpretation that treadmill training may offer an additional benefit. The principal limitation is sample size: thirty participants split across two arms is a small evidence base for a heterogeneous, progressive condition like Duchenne muscular dystrophy, and the abstract does not report effect sizes, confidence intervals, or long-term follow-up. Replication in larger, longer-term trials would be needed before drawing firmer conclusions about clinical relevance or durability of effect.
Both bicycle ergometer and treadmill training groups showed statistically significant within-group improvements in walking capacity and balance after three months of combined therapy.
When directly compared, the treadmill training group showed significantly greater improvement than the bicycle group across all measured outcomes (P<0.05).
The trial included only thirty boys split into two groups of fifteen, a small sample that limits confidence in generalising these findings to broader clinical practice.
Source
Journal of musculoskeletal & neuronal interactions
Sherief AEAA, Abd ElAziz HG, Ali MS · 2021
PMID: 34465672