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Chronic Pain Meta-analysis

The most effective therapeutic exercises for pain intensity in women with fibromyalgia: A systematic review and network meta-analysis.

Researchers looked at 51 randomized controlled trials involving nearly 2,900 women with fibromyalgia to figure out which types of exercise work best for reducing pain. They used a technique called network meta-analysis, which allows them to compare many different exercise approaches at once, even when they haven't all been tested head-to-head. The findings suggest that aquatic exercise (moving in water) appears most effective in the short term, up to three months, while resistance training (strength work) seems to pull ahead in the longer term, beyond three months.

Several other exercise types, including Pilates, qigong, dance, and functional training, also showed improvements compared to usual care. The evidence was rated as moderate in strength, which means the findings are reasonably solid but there's still room for more research to confirm them.

This study looked at which types of exercise seem to help women with fibromyalgia reduce their pain. The good news is that exercise itself does appear to help, and there are several options that research has shown can make a difference.

In the first few months, water-based exercise stood out as the most effective approach. After that initial period, strength training appeared to provide the most benefit.

Other forms of exercise, like dance, Pilates, and qigong, also showed promise in the studies reviewed. It's worth knowing that while these findings are encouraging, researchers emphasize that we still need more studies to be completely certain about these patterns.

What works best may also depend on your own preferences and what feels manageable for your body.

This is a summary of research, not medical advice. Talk to your own healthcare provider about anything affecting your care.

This network meta-analysis synthesized evidence from 51 RCTs to rank exercise interventions for pain reduction in fibromyalgia. The authors identified 15 different exercise approaches and compared them against eight comparators.

Aquatic exercise emerged with the highest probability score (0.87) for short-term pain reduction, while resistance training showed the strongest ranking long-term (0.97). A broader range of interventions showed statistically significant benefits over usual care, including virtual reality, mixed exercise protocols, and aerobic activity, suggesting that exercise modality may matter less than consistent engagement.

The moderate certainty rating reflects reasonable study quality but highlights genuine gaps in the literature, particularly regarding mechanism, optimal dosing, and long-term adherence. The authors explicitly call for more RCTs, indicating that while the ranking is useful, the evidence base remains incomplete enough that individual patient response and preference warrant close clinical observation.

1

Aquatic exercise showed the strongest short-term benefit for pain reduction in women with fibromyalgia, while resistance training was most effective beyond three months.

2

Seven exercise types produced statistically significant improvements in the short term and six in the long term compared to usual care.

3

The evidence base came from 51 randomized controlled trials with nearly 2,900 participants and was rated as moderate in certainty.

Source

Brazilian journal of physical therapy

Rodríguez-Domínguez ÁJ, Rebollo-Salas M, Chillón-Martínez R et al. · 2025

doi: 10.1016/j.bjpt.2025.101226

Read paper →
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A note on accuracy

Summaries are AI-generated from each paper's abstract and are for learning, not clinical decision-making. They may miss nuance or occasionally misstate details from the source, so always read the original paper before applying findings in practice. Nothing on this site is medical advice.