Short-term neurophysiological response after spinal thrust manipulation to guide return-to-throwing in collegiate pitchers: a randomized crossover pilot study.
Featured on Physle Daily · Friday, 21 August 2026
Deciding when a pitcher is ready to return to throwing after treatment is often more art than science, and this small pilot study looked at whether a simple physical test and a measure of pain sensitivity could help. Collegiate baseball pitchers received spinal thrust manipulation (a manual therapy technique) and a sham treatment in a crossover design, with performance and pressure pain threshold measured afterward. A medicine ball scoop test, which measures how far athletes can throw a weighted ball, was the strongest single predictor of throwing velocity.
Adding the change in pressure pain threshold after spinal manipulation to that model improved its predictive strength further. This is interesting because it suggests neurophysiological responses to manual therapy might one day help identify which athletes are best positioned to increase throwing performance, but the study is a small pilot involving one university team, and the findings should be read as preliminary and exploratory rather than a ready-to-use return-to-throwing tool.
If you're a pitcher or work with one, you know that figuring out when someone is ready to return to full throwing after treatment can be tricky. This small study looked at collegiate baseball pitchers to see if a physical test and a measure of pain sensitivity could help predict throwing performance.
Each pitcher tried both a real spinal manipulation treatment and a sham version, and researchers measured how far they could throw a weighted medicine ball plus how their pain sensitivity changed afterward. The medicine ball throw distance turned out to be a strong predictor of pitching velocity, and pitchers whose pain sensitivity changed more after the real manipulation tended to show even stronger prediction of performance.
This is an early, small study though, done at just one university, so it can't tell us yet whether these tests should guide actual return-to-play decisions. Think of it as an interesting first step rather than a settled answer.
This is a summary of research, not medical advice. Talk to your own healthcare provider about anything affecting your care.
This pilot randomised crossover trial recruited collegiate baseball pitchers to compare spinal thrust manipulation against sham manipulation, examining pressure pain threshold and physical performance measures as potential biomarkers for return-to-throwing decisions. As a pilot study, its primary value lies in generating hypotheses and testing measurement feasibility rather than establishing definitive predictive tools, and sample size and generalisability beyond a single Division II program are notable constraints.exploration.
Medicine ball scoop test distance was the strongest single predictor of throwing velocity (R=0.713, R²=0.509, p<0.001), explaining roughly half the variance. Adding the STM-induced change in pressure pain threshold improved the model modestly (R=0.794, R²=0.630, p<0.001), suggesting a possible neurophysiological contribution beyond physical performance alone, though this is a within-subject exploratory model rather than a validated clinical prediction tool.
The crossover design with washout strengthens internal comparison, but the abstract does not report adverse events, retention, or feasibility metrics explicitly, limiting appraisal of practical implementation. These findings should be interpreted as preliminary signal generation warranting larger, adequately powered replication before any clinical application to return-to-throwing protocols.
Medicine ball scoop test distance was the strongest single predictor of throwing velocity, explaining about half the variance (R²=0.509, p<0.001).
Adding the change in pressure pain threshold after spinal thrust manipulation to the model improved predictive power modestly (R²=0.630, p<0.001), suggesting a possible neurophysiological contribution.
This is a small pilot crossover study at a single university, so findings are preliminary and exploratory, not yet validated tools for return-to-throwing decisions.
Source
Research in sports medicine (Print)
Keating C, Lepage M, Adkins R et al. · 2025
doi: 10.1080/15438627.2025.2506121