Physle Daily
Manual Therapy Randomised controlled trial

Effect of post-isometric relaxation versus myofascial release therapy on pain, functional disability, rom and qol in the management of non-specific neck pain: a randomized controlled trial.

This randomised controlled trial compared two manual therapy techniques, post-isometric relaxation and myofascial release therapy, in 60 adults with non-specific neck pain (pain not linked to a specific disease or injury). Thirty participants were assigned to each group and treated over two weeks, with outcomes measured at the first and sixth sessions using pain scores (VAS), a neck disability questionnaire (NDI), goniometer-measured range of motion, and a quality-of-life scale. Both groups showed change over the treatment period, but the post-isometric relaxation group showed statistically significant greater improvement in pain, disability, cervical extension, left rotation, and the social domain of quality of life compared with the myofascial group. The myofascial group showed significantly better improvement in flexion and side-bending range of motion.

The abstract does not report on blinding, dropout, or long-term follow-up, and the small sample size limits how confidently these results can be generalised.

If you've dealt with neck pain that isn't tied to a specific injury, you might wonder whether certain hands-on physiotherapy techniques help more than others. This study looked at two such techniques, post-isometric relaxation (a stretching method using muscle contraction and release) and myofascial release therapy (a soft tissue technique), in 60 people over two weeks, split into two groups of 30. Both groups experienced changes in pain, neck disability, movement, and quality of life by the end of treatment.

The people who received post-isometric relaxation showed statistically greater improvements in pain, disability, certain neck movements, and one aspect of quality of life, compared to those who had myofascial release. However, the myofascial group did better on other movements, like tilting the neck side to side.

This was a relatively small study over a short two-week period, so it doesn't tell us what happens longer term, and the findings shouldn't be assumed to apply broadly to everyone with neck pain.

This is a summary of research, not medical advice. Talk to your own healthcare provider about anything affecting your care.

This RCT randomised 60 patients with non-specific neck pain into two treatment arms (post-isometric relaxation vs myofascial release), assessed via two-way repeated ANOVA across baseline and 2-week follow-up for VAS, NDI, cervical ROM, and WHO QoL-BREF domains. Groups were reported as homogenous at baseline for age and gender. Statistically significant between-group differences favoured post-isometric relaxation for VAS, NDI, cervical extension, left rotation, and the social domain of QoL, while myofascial release showed significantly better outcomes for flexion and bilateral side-bending ROM.

This split-domain pattern suggests the two techniques may have different mechanical or neuromuscular effects rather than one being uniformly superior, though the abstract does not elaborate on mechanism. Key limitations include the modest sample size (30 per group), short 2-week intervention and follow-up period, and no reported information on blinding, allocation concealment adequacy, dropout rates, or adverse events. These factors constrain the strength of conclusions that can be drawn about comparative efficacy or durability of effects beyond the immediate post-treatment window.

1

In this 60-participant RCT, post-isometric relaxation showed statistically significant greater improvement than myofascial release in pain, disability, cervical extension, left rotation, and social quality of life at 2 weeks.

2

Myofascial release therapy showed significantly better improvement in cervical flexion and side-bending range of motion compared with post-isometric relaxation.

3

The trial's small sample size, short 2-week follow-up, and lack of reported blinding or adverse event data limit confidence in how well these findings generalise or persist over time.

Source

BMC musculoskeletal disorders

Khan ZK, Ahmed SI, Baig AAM et al. · 2022

doi: 10.1186/s12891-022-05516-1

Read paper →
Previously in Manual Therapy
2026-08-08A Single-Center Study Comparing the Effects of Thoracic Spine Manipulation vs Mobility Exercises in 26 Office Workers with Chronic Neck Pain: A Randomized Controlled Clinical Study.2026-08-07Which Portion of Physiotherapy Treatments' Effect Is Not Attributable to the Specific Effects in People With Musculoskeletal Pain? A Meta-Analysis of Randomized Placebo-Controlled Trials.2026-08-06The Clinical Significance of Mulligan's Mobilization with Movement in Shoulder Pathologies: A Systematic Review and Meta-Analysis. Browse the full Manual Therapy archive →
A note on accuracy

Summaries are AI-generated from each paper's abstract and are for learning, not clinical decision-making. They may miss nuance or occasionally misstate details from the source, so always read the original paper before applying findings in practice. Nothing on this site is medical advice.