Temporomandibular joint rehabilitative approaches for children and adolescents affected by juvenile idiopathic arthritis: A systematic review.
Featured on Physle Daily · Saturday, 17 October 2026
Temporomandibular joint involvement is common in juvenile idiopathic arthritis, affecting an estimated 39 to 78 percent of young patients, yet it is not always clear which conservative treatments actually help the joint. This review pulled together 13 observational studies looking at approaches such as corticosteroid injections directly into the joint, infliximab injections, arthrocentesis (a joint-flushing procedure), occlusal splints, functional dental appliances, and physiotherapy. Across these studies, corticosteroid injections into the joint were the most consistently reported as helpful, appearing effective in eight of the included studies. Infliximab injections, by contrast, did not appear to meaningfully improve joint arthritis.
The main limitation is that all the included studies were observational rather than randomised trials, with relatively small and not fully representative samples, so these findings point toward promising directions rather than settled answers, and the authors call for stronger research before firmer conclusions can be drawn.
If you are a parent of a child with juvenile idiopathic arthritis, you may already know that the jaw joint can be affected, sometimes without obvious symptoms early on. This review looked at the research evidence behind several non-surgical treatments used for this jaw joint problem, including steroid injections directly into the joint, a different type of injection called infliximab, a joint-flushing procedure, mouth splints, dental appliances, and physiotherapy. Pulling together 13 studies, the review found that steroid injections into the joint were reported as helpful in most of the studies that tested them.
Infliximab injections did not show a similar improvement. It's worth understanding that all of these studies were observational, meaning children were followed and treatments compared without the stricter controls of a randomised trial, so the results, while encouraging for steroid injections, are not yet definitive.
More rigorous research is needed before firm conclusions can be drawn about what works best for the jaw joint in this condition.
This is a summary of research, not medical advice. Talk to your own healthcare provider about anything affecting your care.
This review addresses what the current observational evidence says about conservative management of temporomandibular joint arthritis in juvenile idiopathic arthritis, a question relevant given the joint is affected in an estimated 39 to 78 percent of patients. It synthesises 13 observational studies covering intra-articular corticosteroid injections, intra-articular infliximab injections, arthrocentesis alone or combined with corticosteroid injection, occlusal splints, functional appliances, and physiotherapy, with clinical or radiological assessment of temporomandibular joint arthritis as the outcome. The most consistent signal across the body of evidence was for intra-articular corticosteroid injections, reported as effective in eight of the included studies, while infliximab injections did not appear to produce a similar benefit.
For physiotherapists, this informs an understanding of where corticosteroid injection sits in the broader conservative management picture alongside splints, appliances, and physiotherapy interventions, though the abstract does not detail physiotherapy's specific outcomes relative to the other approaches, nor does it report a head-to-head comparison establishing superiority of any single approach. Crucially, because all included studies were observational rather than randomised, with smaller and less representative samples, the review cannot establish causation or rule out confounding, and the authors themselves call for higher-quality studies with larger, more representative cohorts before these findings should inform practice changes.
A systematic review of 13 observational studies found that intra-articular corticosteroid injections into the temporomandibular joint were reported as effective in eight studies among children and adolescents with juvenile idiopathic arthritis.
Intra-articular infliximab injections did not appear to significantly improve temporomandibular joint arthritis, unlike corticosteroid injections.
The evidence base is limited to observational studies with small, less representative samples, so confidence in these conservative treatment approaches remains preliminary.
Source
International journal of paediatric dentistry
Ferrillo M, Gallizzi R, Marotta N et al. · 2025
doi: 10.1111/ipd.13225