Neuromuscular training for preventing knee injuries in female team athletes: a meta-analysis.
Featured on Physle Daily · Tuesday, 25 August 2026
Knee injuries, including anterior cruciate ligament (ACL) tears, remain a persistent problem in women's team sports, and coaches and clinicians have long looked to neuromuscular training programs, which combine drills like balance, strength, agility, and jumping mechanics, as a way to reduce that risk. This meta-analysis pooled randomized controlled trials comparing such training programs against usual training or control conditions in female team-sport athletes. Overall, the pooled evidence showed a reduction in knee injury risk, with an even larger reduction for ACL injuries specifically. What stood out was that how consistently athletes actually did the training mattered more than how complex the program was.
Sessions of at least 15 minutes, done two to three times a week, and programs including agility or running mechanics work were linked to better outcomes. As with any meta-analysis, results depend on the quality and consistency of the underlying trials, and the abstract does not detail heterogeneity or risk of bias across studies, which limits how confident we can be in the precise size of the effect.
If you play a team sport, you've probably heard about warm-up routines meant to protect your knees, especially your ACL, from injury. This research pooled data from multiple clinical trials testing structured training programs, often involving balance, strength, and movement drills, in female team-sport athletes.
The combined evidence suggests these programs are associated with fewer knee injuries overall, and a notably larger reduction in ACL injuries specifically, compared to standard training. Interestingly, the biggest factor tied to better results wasn't how complicated or advanced the program was. It was how consistently athletes actually completed the sessions, defined here as sticking with at least three-quarters of planned training.
Programs run for 15 minutes or more, two to three times weekly, and those that included agility or running-technique work, showed the strongest links to reduced injury risk. It's worth understanding that this is a summary of existing studies rather than one large new trial, and the abstract doesn't detail how consistent or reliable those individual studies were, so the exact size of the benefit should be viewed as an estimate rather than a certainty.
This is a summary of research, not medical advice. Talk to your own healthcare provider about anything affecting your care.
This PRISMA-guided meta-analysis pooled randomized controlled trials evaluating neuromuscular training for knee injury prevention in female team-sport athletes, drawing on five major databases through December 2024. Pooled analysis found a 22% reduction in overall knee injury risk (RR 0.78, 95% CI 0.65-0.94, p=0.008) and a 50% reduction in ACL injury risk (RR 0.50, 95% CI 0.31-0.81, p=0.005), both statistically significant. Subgroup analyses identified compliance of 75% or higher as the strongest predictor of benefit (RR 0.67, 95% CI 0.51-0.87, p=0.004), outperforming program complexity itself.
Sessions exceeding 15 minutes (RR 0.74, 95% CI 0.60-0.93) and frequencies of two to three per week (RR 0.87, 95% CI 0.76-0.99) were independently associated with reduced risk, as were programs incorporating agility (RR 0.71, 95% CI 0.56-0.88) or running mechanics training (RR 0.80, 95% CI 0.70-0.93). The abstract does not report heterogeneity statistics, risk-of-bias assessment, or the exact number of included trials and participants, which constrains judgment of certainty and the generalizability of these dose-response subgroup findings. The authors note that standardizing exposure metrics and sensor-based compliance tracking could improve future evidence quality.
Pooled data across randomized trials showed a 22% reduction in overall knee injury risk and a 50% reduction in ACL injury risk with neuromuscular training compared to control conditions.
Training compliance of at least 75% was the strongest predictor of injury reduction, outperforming the complexity of the training program itself.
The abstract does not report heterogeneity or risk-of-bias details across the pooled trials, so the exact certainty and consistency of these dose-response findings remain unclear.
Source
Annals of medicine
Gu J, Zhang R, Zhang Y et al. · 2025
doi: 10.1080/07853890.2025.2581891