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Manual Therapy Randomised controlled trial

Effects of instrument-assisted soft tissue mobilization combined with exercise on knee joint muscle activity during walking in patients with moderate knee osteoarthritis: A randomized controlled clinical trial.

People with knee osteoarthritis often walk with extra muscle activity around the joint, which may add to wear and discomfort. This small trial asked whether instrument-assisted soft tissue mobilization, a manual therapy technique using handheld tools to work on soft tissue, adds anything useful when combined with exercise therapy. Thirty patients with moderate knee osteoarthritis were randomly assigned to real instrument-assisted treatment plus exercise or a sham version of the same treatment plus exercise, over four sessions across two weeks. Both groups improved in pain, disability, and strength, but the group receiving the real technique showed greater improvements and also showed reductions in electrical muscle activity in several leg muscles during walking, while the sham group's activity tended to increase.

This pattern suggests the added treatment might help the muscles around the knee work more efficiently, though with only thirty participants and a short two-week intervention, the findings should be seen as preliminary rather than conclusive.

If you have knee osteoarthritis, you may have noticed your leg muscles working harder than expected just to walk, which research suggests can happen as the body tries to protect a sore joint. This study looked at whether adding a manual therapy technique called instrument-assisted soft tissue mobilization, which uses handheld tools on the soft tissue around the knee, helps on top of a standard exercise program. Thirty people with moderate knee osteoarthritis took part, with half receiving the real technique plus exercise and half receiving a fake version of the technique plus the same exercise.

After two weeks, everyone reported less pain and disability and showed improved strength, but those who got the real technique improved more and showed drops in muscle activity measured during walking, while the comparison group's muscle activity tended to rise. Because this was a small, short study, the results are encouraging but preliminary, and larger studies would be needed to confirm whether this approach makes a lasting difference.

This is a summary of research, not medical advice. Talk to your own healthcare provider about anything affecting your care.

This trial addresses whether instrument-assisted soft tissue mobilization (IASTM) adds measurable neuromuscular benefit when combined with exercise therapy for moderate knee osteoarthritis, beyond what exercise and attention alone might produce. Thirty patients were randomised to IASTM plus exercise or sham IASTM plus exercise for four sessions over two weeks, with electromyographic (EMG) activity, co-contraction indices, pain, strength, and disability assessed pre- and post-treatment during preferred and fast walking. The decisive finding was a significant group-by-time interaction for vastus medialis, semitendinosus, and tibialis anterior EMG activity, decreasing in the IASTM group and increasing in the sham group, with a similar but speed-dependent trend for vastus lateralis during fast walking.

Both groups improved in pain, strength, and disability, but the IASTM group showed significantly greater gains on these measures. EMG activity in several muscles correlated with pain and strength, suggesting a link between neuromuscular load and symptom burden, though correlation does not establish causation. Because the sham group also received exercise and therapist contact, the comparison isolates the added contribution of the soft-tissue technique itself rather than testing it against no treatment.

The small sample, short two-week duration, and single-trial evidence base mean these neuromuscular findings should be interpreted as exploratory rather than a basis for changing practice.

1

In this small randomised trial of thirty patients, EMG activity in vastus medialis, semitendinosus, and tibialis anterior decreased after IASTM plus exercise but increased after sham IASTM plus exercise.

2

Both groups improved in pain, strength, and disability over two weeks, but the IASTM group showed significantly greater improvements than the sham group.

3

Findings come from a single small trial with a short two-week intervention, so the neuromuscular results should be considered preliminary rather than confirmed.

Source

Scientific reports

Jafarsalehi B, Boozari S, Torkaman G · 2025

doi: 10.1038/s41598-025-28418-3

Read paper →
Previously in Manual Therapy
2026-10-03Efficacy of instrument-assisted soft tissue mobilization on patients with neck pain: a systematic review and meta-analysis of randomized trials.2026-10-02Effects of matched vs. unmatched physical therapy interventions on pain or disability in patients with neck pain - a systematic review and meta-analysis.2026-10-01Swedish massage versus hip strengthening exercises for pain and function in older adults with knee osteoarthritis: a randomized controlled trial. Browse the full Manual Therapy archive →
A note on accuracy

Summaries are AI-generated from each paper's abstract and are for learning, not clinical decision-making. They may miss nuance or occasionally misstate details from the source, so always read the original paper before applying findings in practice. Nothing on this site is medical advice.